A dominant yet wasteful Real ravaged their rivals in the first half while spurning a string of clear chances at the Santiago Bernabeu.
The win increased Zinedine Zidane's side's advantage at the top of the standings to six points
Barcelona beat Girona 2-0 in a Catalan derby on Sunday to maintain their five-point lead at the top of La Liga, while Real Madrid thrashed Espanyol 4-2.
Real Madrid have enviously looked on as Barcelona claimed six La Liga titles in the last eight years, but Zinedine Zidane's side can take a huge step towards a first crown since 2012 with victory over their bitter rivals at the Nou Camp on Saturday.
A weekend of surprise results across Europe's big leagues saw Bayern Munich's unbeaten run come to an end, Napoli knocked off top spot in Serie A and Manchester City toppled in the Premier League where Leicester City are the new leaders.
Eden Hazard expects to enjoy playing with greater freedom and less pressure on his shoulders this season as Premier League leaders Chelsea demonstrate their strength in depth by challenging for four trophies, including the Champions League.
Diego Costa gave Europa League holders Atletico a dream start against Champions League winners Real by firing them ahead after 49 seconds, knocking down a long pass and smashing the ball into the net from a tight angle.
IMAGES from La Liga matches played on Sunday
Real Madrid completed their pre-season tour of Australia with a crushing 4-1 friendly win over a depleted Manchester City in front of a record soccer crowd of 99,382 at the Melbourne Cricket Ground on Friday.
Barcelona finished three points behind Real Madrid last season but there is concern the gap between Spain's biggest two sides could be far larger this season.
Barcelona thrashed Sporting Gijon 6-1 to go top of La Liga on a dramatic night in Spain on Wednesday as Luis Enrique announced he was stepping down as the Catalan club's coach at the end of the season.
'They probably need to refresh the team a bit more, to be very honest. They have kept the majority of the same team for the last couple of years'
Real are unbeaten since February, winning 10 of their last 12 games. In contrast, Barcelona have won just two of their previous five in all competitions and were dumped out of Europe in midweek.
Real Madrid captain Sergio Ramos again came to his side's rescue as they snatched a dramatic 3-2 victory over Deportivo La Coruna on Saturday to keep Zinedine Zidane's side six points clear at the top of La Liga and set a club record 35 games unbeaten.
Belgian league leaders Antwerp secured a shock 1-0 win over Tottenham Hotspur and AC Milan extended their unbeaten run to 23 games as they won 3-0 against Sparta Prague in the Europa League on Thursday, while Arsenal cruised to a 3-0 win over Dundalk.
Chelsea moved into the Premier League's top four as Mason Mount's superb first-half goal earned them a 1-0 win at champions Liverpool who suffered a club-record fifth straight home league defeat on Thursday.
Cristiano Ronaldo continued his prolific start to the season with four goals, including two penalties, as Real Madrid came from behind to beat Elche 5-1 in La Liga on Tuesday.
Cristiano Ronaldo netted his 27th career hat-trick and Gareth Bale struck twice as Real Madrid bounced back in style from consecutive defeats with a thumping 8-2 La Liga win at Deportivo La Coruna on Saturday.
Croatia, helped by a mistake by veteran goalkeeper Gianluigi Buffon, held Italy to a 1-1 away draw on Sunday, but their evening was ruined by their fans who twice interrupted play by throwing flares onto the pitch.
Wales continued their unbeaten start to the Euro 2016 campaign as a nervy 2-1 triumph over Cyprus, after they had been reduced to 10 men, bolstered the nation's dream of qualifying for a major championship finals for only the second time.
Karius's manager Juergen Klopp said the keeper will be backed by the club.
Cristiano Ronaldo may have played his last game for Real Madrid after winning a fourth Champions League crown with the Spanish side in a 3-1 victory over Liverpool on Saturday, saying he would soon make an announcement on his future.
Leaders Real Madrid pulled three points clear of second-placed Celta Vigo when they held off the valiant 10-man Galicians to secure a nervy 3-1 victory in Saturday's top-of-the-table clash in La Liga.
News of all that's transpired on and off the football field
Alvaro Morata again proved decisive from the bench by striking a late winner against Athletic Bilbao and firing a lacklustre Real Madrid to the top of La Liga on Sunday. The Spain international has been afforded limited opportunities in his first season back at Real following two years with Juventus, struggling to usurp first choice forwards Gareth Bale, Cristiano Ronaldo and Karim Benzema. Morata has made just four league starts, but has scored four times in all competitions.
Cristiano Ronaldo showed nerves of steel to score an injury-time penalty and send holders Real Madrid into the semi-finals of the Champions League in extraordinary circumstances as they lost 3-1 to Juventus on Wednesday but won a thrilling tie 4-3 on aggregate.
Aymeric Laporte's late header sealed a deserved 1-0 victory over Tottenham Hotspur
The stadiums at Qatar offer plenty of wisdom and chutzpah on how to take our own lives forward.
Holders Real Madrid were sensationally knocked out of the Champions League on Tuesday after being thrashed 4-1 at home by an outstanding Ajax Amsterdam who overturned a first-leg deficit to reach the quarter-finals 5-3 on aggregate.
Spain started their World Cup qualifying campaign with a crushing 8-0 win over Liechtenstein, laying down a marker in Group G with a ruthless second-half display on Monday.
Just as he did two years ago, Sergio Ramos left his footprint all over Real Madrid's Champions League final triumph over Atletico Madrid following a turbulent 12 months.
Leicester City coach Claudio Ranieri said on Tuesday that he believed at Christmas his team would win the Premier League, even as he continued to tell the media his only goal was avoiding relegation. "Now I can say it, I always knew we'd win," Ranieri told Italian daily Il Fatto Quotidiano the day after Leicester's triumph. He said he had always denied any championship ambitions until almost the end of the season because "that's the way I am made, I have always preferred doing things rather than talking about them". Asked to pinpoint when he really became convinced Leicester could win, he said: "It was at Christmas. Relegation had been avoided and we gathered together to talk in the changing rooms and we said to each other, 'Let's go for it, we've got nothing to lose'." Ranieri played down his own role in the achievement, saying that teamwork was key to the club's success and his players had no shortage of ability.
Suarez moved ahead of Ronaldo as the league's top scorer on 34 goals after netting four times, twice with penalties, in the space of 25 second-half minutes
Cristiano Ronaldo grabbed a record 23rd La Liga hat-trick to guide leaders Real Madrid to a 3-0 victory over Celta Vigo. It also helped the European champions extend their club record winning streak to 18 matches in all competitions.
Quaison fires Sweden to extra-time World Cup playoff win over Czechs
Liverpool manager Brendan Rodgers believes his team are back to their sizzling form of last season after a superb victory over Tottenham defied those who predicted a gloomy outlook in the post-Luis Suarez era.
The FIFA 2022 World Cup will kick-off in Qatar on Sunday, November 20. Here is a list of the 26-man squads playing in the quadrennial global football extravaganza.
Portugal became the first team to qualify for the Nations League semi-finals when they held Italy 0-0 on Saturday, the second time in a year that the hosts have been knocked out of a competition following a goalless draw at the San Siro.
La Liga's reputation as the epicenter of world soccer talent has been bruised by the world record smashing sale of Neymar to Paris St Germain and how Barcelona react to the departure of one of their leading players will define the new season in Spain.
The Dutch, who have not missed a Euro finals since 1984, kept their playoff chances alive with a 2-1 win in Kazakhstan